Cytokine-Induced Pathology, Part B : Inflammatory Cytokines, Receptors, and Disease

This two-volume set is a comprehensive review of the "in vivo" effects in experimental animals induced by several members of the cytokine family. The volumes explain the pharmacological and toxico-pathological effect of such hematopoietic growth factors as colony stimulating factor, the novel factors IL-11 and stem cell factors. Then it summarizes the broad spectrum of activity of several immunostimulatory assays (interleukins IL-1-IL-9) in conventional toxicological assays as well as results from transgenic models. The set also features the inflammatory cytokines (IL-1, TNFa and beta, interfereon-g and TGF-beta) competently reviewed by experts in the field. The set reviews the structure and distribution of the membrane receptors for these growth factors. It addresses the role of various cytokines in disease processes (malaria, sepsis, and meningitis). Volumes 34A and 34B also cover the clinical experience with two growth factors (interferons and GM-CSF), which clearly show that the preclinical data were predictive and valuable for the clinician. Each volume of "International Review of Experimental Pathology" contains an index, and each chapter includes references